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Research Technician - Electron Microscopy, De Camilli Lab

We are currently seeking a dynamic, interested, and curious Research Technician within the lab of Dr. Pietro De Camilli at Yale University. The De Camilli Lab studies mechanisms underlying the dynamics and traffic of intracellular membranes, with emphasis on membrane transport reactions involved in neurotransmission. Their work sits at the intersection of fundamental biology and neuroscience, including neurodegenerative diseases, Parkinson’s disease in particular.  More information on the lab can be found on their website.

This role will be integral to the functioning of the lab, and assist the ongoing research support focused on Electron Microscopy (EM) in a laboratory of cell biology and cellular neurobiology.  Under the guidance and supervision of the Principal Investigator and other members of the lab, the Research Technician will perform EM analysis (including electron tomography and FIB-SEM) and will participate in the preparation of material for EM observation. Other techniques may include digital light microscopy and tissue culture.  We are looking for a self-driven individual who is eager to learn and absorb the nuances of EM work within the De Camilli Lab, and expand on their current skillset.  This is an excellent entry-level opportunity for someone looking to build their career in the world of modern EM techniques.

  • Conduct experiments independently after discussion of the plan with supervisor.  Interpret experimental results independently and in consultation with supervisor and collaborators in the lab.
  • Work with an electron microscope, prepare specimens and sections for light and electron microscopy, observe samples, collect images, store and process them via digital techniques. 
  • Perform immunolabeling experiments.
  • Collect data set using FIB-SEM (Focused Ion Beam Scanning Electron Microscopy)
  • Use image analysis programs
  • Help with routine functions of the lab in cooperation with other support personnel, such as:
  • Maintaining and ordering laboratory reagents and supplies, managing inventories, generating stocks solutions of general use, maintain culture cell lines etc.

  • Bachelor’s degree in Biology or a related field, or equivalent education
  • Prior experience with histology and basic biochemical techniques

  • Prior experience with electron microscopy or microscopy preferred
  • Ability to work both independently and in a team setting
  • Good organizational and analytical skills, excellent fine motor skills, and strong attention to detail
  • Ability to follow protocols and maintain a detailed laboratory notebook.
  • Willingness to learn
  • Passion for creating excellent microscopy images

Physical Requirements
Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet).
Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis.

Please Note:
This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however.  Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act.

HHMI is an Equal Opportunity Employer